Application of multiancestry and ensemble-based approaches yields improved polygenic risk prediction models for breast cancer and its subtypes among women of African ancestry.

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

A genus-wide super-pangenome across 16 tomato species generated by integrating 20 telomere-to-telomere genome assemblies and 27 published genomes identifies structural variants associated with salinity or disease resistance for molecular breeding.

Swave is a method to call structural variants from pangenome graphs using a recurrent neural network to identify structural variant patterns, including complex structural variants.

This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and diseased skin.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

SingleBrain integrates publicly available single-nucleus RNA sequencing and genotype data from 983 individuals of European ancestry, mapping eQTLs across major brain cell types and subtypes and providing insights into the genetic regulation of brain disorders.

Single-cell expression quantitative trait locus analyses of the human cerebellar cortex coupled with Mendelian randomization highlight a crucial role for oligodendrocytes in the pathogenesis of essential tremor.

Genomics-guided design of ideotype maize through pyramiding favorable alleles led to hybrid maize varieties suitable for high-density planting, with enhanced yield.

NCR1 (nitrate concentration regulator 1) promotes root-to-shoot nitrate transport by regulating the transcription of nitrate transporter NRT2.3, thereby contributing to grain yield in maize.