This study presents an acoustic resonance–assisted direct ink printing strategy to create structured energetic composites with enhanced and tunable energy release, revealing how multiscale design influences performance and enabling new additive manufacturing pathways for energetic systems.

Ma, Li, and colleagues present a virtual tissue staining method that overcomes data mismatch by separating image generation from spatial alignment. This approach produces highly accurate diagnostic images that expert pathologists cannot distinguish from real chemical stains.

Bio-interfaced applications are limited by the transfer of soft electronic devices onto high curvature and fragile surfaces. Here, the authors develop a stress-responsive transfer fluid that enables distortion-free, adhesion-switchable transfer for conformal integration and stable real-time bioelectronic sensing.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

High-level electronic structure calculations reveal unusually strong interactions between Cu(I) sites and helium, enabling selective separation of helium isotopes at practical, technologically relevant temperatures.

This work establishes a unified framework where mantle plumelet dynamics, slab segmentation, and drip-like arc removal govern multi-scale deformation and seismicity in the Arabian-Eurasian post-subduction collision.

A fundamental question in ecology is whether species-rich communities tend to exhibit high ecological uniqueness. This study suggests that a negative association between species richness and ecological uniqueness is widespread across diverse taxa groups, and that the drivers of this relationship vary depending on whether species presence or abundance is considered.

Enhanced quasi-biennial variability of East Asian Summer Monsoon rainfall over the Yangtze River Basin, along with more frequent floods in recent decades, is linked to intensified and faster baroclinic wave activity in the tropical Indian Ocean.

Editorial summary: Observations show that tropical rainfall changes over the past four decades are driven primarily by shifts in atmospheric circulation rather than increases in atmospheric moisture. Land warming and ongoing desertification in the Northern Hemisphere, together with Indo-Pacific warm pool warming, emerge as key drivers of these hydroclimate changes.

The authors use a physiological approach, finding recent extreme heat events had deadly heat stress conditions, particularly for fully exposed older people. Conditions were well below wet-bulb temperatures of 35˚C, a common heat stress indicator.

GGCX catalyzes vitamin K–dependent γ-carboxylation of glutamate residues. Here, the authors report its complex structures with multiple canonical substrates, elucidate the propeptide recognition mechanism, and identify three substrate-loading modes.

Host defense requires coordination between epithelial sensing and systemic responses. Here, the authors show that proton signaling links intestinal pathogen detection to motor neurons, promoting avoidance behavior and innate immunity in C. elegans.

This work develops DJX-A-KM, a small-molecule KRASG12C degrader that recruits E3 ligase FBXO28 via dual covalent binding, inducing potent degradation. This strategy can possibly be extended to pan-KRAS degraders against a broader spectrum of KRAS mutations.

Cyclic di-GMP, a bacterial second messenger, governs many cellular processes including bacterial lifestyle transitions. Here, authors develop a set of FRET-based biosensors that enables them to monitor real-time cellular dynamics of c-di-GMP and to perform a genome-wide analysis that reveals complex interplay between motility and c-di-GMP regulation.

Available genomic prediction models lack scalability and interpretability. The authors introduce a deep learning framework that incorporates GWAS derived SNP weights into a hybrid CNN Transformer architecture, improving prediction accuracy and interpretability in soybean, maize, rice, and wheat.

Ma, Li, and colleagues present a virtual tissue staining method that overcomes data mismatch by separating image generation from spatial alignment. This approach produces highly accurate diagnostic images that expert pathologists cannot distinguish from real chemical stains.

Mirvetuximab soravtansine (MIRV) is an antibody drug conjugate comprised of a folate receptor alpha-targeted monoclonal antibody and the anti-tubulin maytansinoid payload, DM4. Here the authors report the results of a phase II trial of MIRV in combination with anti-PD1 pembrolizumab in patients with recurrent folate receptor alpha-positive uterine serous carcinoma.

This long-term, large-scale intervention and follow-up MRI study suggests that sustained visceral fat loss, rather than weight loss, is linked to better cognition and attenuation of brain atrophy years later, mainly via improved glycaemic control.

The authors reveal that parents’ genes influence the risk of smoking in their adult offspring not only through inheritance, but also via the rearing environments the parents provide − a pathway called genetic nurture.

The authors identify a KAT8 K145 lactylation switch that enhances TIP60 dependent p53 K120 acetylation and proapoptotic transcription, implicating this axis in doxorubicin cardiotoxicity and its mitigation by glimepiride.

Environmental Robustness Index is established to bridge the gap between laboratory and field performance of solar evaporation technologies. Design principles for managing heat transport enable stable water production in diverse climatic conditions.

Psychology studies are becoming more global, yet often rely on highly educated participants. The authors find, across 95 countries, that higher education predicts cultural similarity to WEIRD societies, such as the United States.

The authors use a physiological approach, finding recent extreme heat events had deadly heat stress conditions, particularly for fully exposed older people. Conditions were well below wet-bulb temperatures of 35˚C, a common heat stress indicator.

Ibiza, an island in present-day Spain, was under Islamic rule between the 10^th and 13^th centuries CE. Here, the authors analyse the remains of thirteen individuals from medieval Islamic burials in Ibiza, describing their ancestries and pathogens.

Traditional quiz scores provide limited insight into what students know. Here, the authors show that text embedding models combined with short multiple-choice quizzes yield detailed maps of conceptual knowledge and learning.